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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1975 1
1976 1
1980 1
1981 4
1982 1
1983 1
1985 1
1987 3
1988 1
1989 2
1990 2
1991 6
1992 7
1993 7
1994 10
1995 10
1996 18
1997 16
1998 9
1999 18
2000 24
2001 18
2002 23
2003 18
2004 18
2005 17
2006 22
2007 14
2008 21
2009 23
2010 19
2011 15
2012 26
2013 29
2014 39
2015 50
2016 60
2017 66
2018 67
2019 89
2020 89
2021 100
2022 125
2023 118
2024 65

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1,137 results

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Page 1
Structure of the activated human minor spliceosome.
Bai R, Wan R, Wang L, Xu K, Zhang Q, Lei J, Shi Y. Bai R, et al. Science. 2021 Mar 19;371(6535):eabg0879. doi: 10.1126/science.abg0879. Epub 2021 Jan 28. Science. 2021. PMID: 33509932
The minor spliceosome mediates splicing of the rare but essential U12-type precursor messenger RNA. Here, we report the atomic features of the activated human minor spliceosome determined by cryo-electron microscopy at 2.9-angstrom resolution. The 5' splice s …
The minor spliceosome mediates splicing of the rare but essential U12-type precursor messenger RNA. Here, we report the atomic …
Structural mechanisms for regulation of GSDMB pore-forming activity.
Zhong X, Zeng H, Zhou Z, Su Y, Cheng H, Hou Y, She Y, Feng N, Wang J, Shao F, Ding J. Zhong X, et al. Nature. 2023 Apr;616(7957):598-605. doi: 10.1038/s41586-023-05872-5. Epub 2023 Mar 29. Nature. 2023. PMID: 36991125
The structure of full-length GSDMB suggests stronger autoinhibition than in other gasdermins(9,10). GSDMB has multiple splicing isoforms that are equally targeted by IpaH7.8 but exhibit contrasting pyroptotic activities. ...Our study illustrates fine regulation of GSDMB po …
The structure of full-length GSDMB suggests stronger autoinhibition than in other gasdermins(9,10). GSDMB has multiple splicing isofo …
SRSF10 is essential for progenitor spermatogonia expansion by regulating alternative splicing.
Liu W, Lu X, Zhao ZH, Su R, Li QL, Xue Y, Gao Z, Sun SS, Lei WL, Li L, An G, Liu H, Han Z, Ouyang YC, Hou Y, Wang ZB, Sun QY, Liu J. Liu W, et al. Elife. 2022 Nov 10;11:e78211. doi: 10.7554/eLife.78211. Elife. 2022. PMID: 36355419 Free PMC article.
However, how alternative splicing regulates spermatogenesis remains largely unknown. Here, using a germ cell-specific knockout mouse model, we demonstrated that the splicing factor Srsf10 is essential for spermatogenesis and male fertility. ...This was further evide …
However, how alternative splicing regulates spermatogenesis remains largely unknown. Here, using a germ cell-specific knockout mouse …
Bud31-mediated alternative splicing is required for spermatogonial stem cell self-renewal and differentiation.
Qin J, Huang T, Wang Z, Zhang X, Wang J, Dang Q, Cui D, Wang X, Zhai Y, Zhao L, Lu G, Shao C, Li S, Liu H, Liu Z. Qin J, et al. Cell Death Differ. 2023 Jan;30(1):184-194. doi: 10.1038/s41418-022-01057-1. Epub 2022 Sep 16. Cell Death Differ. 2023. PMID: 36114296 Free PMC article.
Alternative splicing (AS) is tightly regulated during cell differentiation and development. AS events are prevalent in the testis, but the splicing regulation in spermatogenesis remains unclear. Here we report that the spliceosome component Bud31 plays a crucial rol …
Alternative splicing (AS) is tightly regulated during cell differentiation and development. AS events are prevalent in the testis, bu …
Extracellular nanovesicles for packaging of CRISPR-Cas9 protein and sgRNA to induce therapeutic exon skipping.
Gee P, Lung MSY, Okuzaki Y, Sasakawa N, Iguchi T, Makita Y, Hozumi H, Miura Y, Yang LF, Iwasaki M, Wang XH, Waller MA, Shirai N, Abe YO, Fujita Y, Watanabe K, Kagita A, Iwabuchi KA, Yasuda M, Xu H, Noda T, Komano J, Sakurai H, Inukai N, Hotta A. Gee P, et al. Nat Commun. 2020 Mar 13;11(1):1334. doi: 10.1038/s41467-020-14957-y. Nat Commun. 2020. PMID: 32170079 Free PMC article.
Chemical induced dimerization recruits Cas9 protein into extracellular nanovesicles, and then a viral RNA packaging signal and two self-cleaving riboswitches tether and release sgRNA into nanovesicles. ...
Chemical induced dimerization recruits Cas9 protein into extracellular nanovesicles, and then a viral RNA packaging signal and two se …
Splicing factor BUD31 promotes ovarian cancer progression through sustaining the expression of anti-apoptotic BCL2L12.
Wang Z, Wang S, Qin J, Zhang X, Lu G, Liu H, Guo H, Wu L, Shender VO, Shao C, Kong B, Liu Z. Wang Z, et al. Nat Commun. 2022 Oct 21;13(1):6246. doi: 10.1038/s41467-022-34042-w. Nat Commun. 2022. PMID: 36271053 Free PMC article.
Dysregulated expression of splicing factors has important roles in cancer development and progression. However, it remains a challenge to identify the cancer-specific splicing variants. Here we demonstrate that spliceosome component BUD31 is increased in ovarian can …
Dysregulated expression of splicing factors has important roles in cancer development and progression. However, it remains a challeng …
Structural basis of pre-tRNA intron removal by human tRNA splicing endonuclease.
Zhang X, Yang F, Zhan X, Bian T, Xing Z, Lu Y, Shi Y. Zhang X, et al. Mol Cell. 2023 Apr 20;83(8):1328-1339.e4. doi: 10.1016/j.molcel.2023.03.015. Epub 2023 Apr 6. Mol Cell. 2023. PMID: 37028420 Free article.
Removal of the intron from precursor-tRNA (pre-tRNA) is essential in all three kingdoms of life. In humans, this process is mediated by the tRNA splicing endonuclease (TSEN) comprising four subunits: TSEN2, TSEN15, TSEN34, and TSEN54. ...Such recognition orients the antico …
Removal of the intron from precursor-tRNA (pre-tRNA) is essential in all three kingdoms of life. In humans, this process is mediated by the …
Systematic discovery of biomolecular condensate-specific protein phosphorylation.
Sridharan S, Hernandez-Armendariz A, Kurzawa N, Potel CM, Memon D, Beltrao P, Bantscheff M, Huber W, Cuylen-Haering S, Savitski MM. Sridharan S, et al. Nat Chem Biol. 2022 Oct;18(10):1104-1114. doi: 10.1038/s41589-022-01062-y. Epub 2022 Jul 21. Nat Chem Biol. 2022. PMID: 35864335 Free PMC article.
Here, we combine solubility proteome profiling with phosphoproteomics to quantitatively map several hundred phosphosites enriched in either soluble or condensate-bound protein subpopulations, including a subset of phosphosites modulating protein-RNA interactions. We show t …
Here, we combine solubility proteome profiling with phosphoproteomics to quantitatively map several hundred phosphosites enriched in either …
RNA binding proteins in osteoarthritis.
Yi Q, Deng Z, Yue J, He J, Xiong J, Sun W, Sun W. Yi Q, et al. Front Cell Dev Biol. 2022 Aug 8;10:954376. doi: 10.3389/fcell.2022.954376. eCollection 2022. Front Cell Dev Biol. 2022. PMID: 36003144 Free PMC article. Review.
Osteoarthritis (OA) is a common chronic degenerative joint disease worldwide. The pathological features of OA are the erosion of articular cartilage, subchondral bone sclerosis, synovitis, and metabolic disorder. ...RBPs regulate RNA subcellular localization, stabil …
Osteoarthritis (OA) is a common chronic degenerative joint disease worldwide. The pathological features of OA are the erosion of arti …
The hallmarks of myotonic dystrophy type 1 muscle dysfunction.
Ozimski LL, Sabater-Arcis M, Bargiela A, Artero R. Ozimski LL, et al. Biol Rev Camb Philos Soc. 2021 Apr;96(2):716-730. doi: 10.1111/brv.12674. Epub 2020 Dec 2. Biol Rev Camb Philos Soc. 2021. PMID: 33269537 Review.
This leads to the sequestration of the muscleblind-like (MBNL) family of proteins, depleting them, and the abnormal stabilisation of CUGBP Elav-like family member 1 (CELF1), enhancing it. Traditionally, DM1 research has focused on this RNA toxicity and how it alters MBNL a …
This leads to the sequestration of the muscleblind-like (MBNL) family of proteins, depleting them, and the abnormal stabilisation of CUGBP E …
1,137 results